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Can experimental blood test diagnose Alzheimer’s disease?

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Alzheimer’s disease can be finally diagnosed in its first steps.

An experimental blood test can accurately diagnose Alzheimer’s disease, the most common form of dementia, according to a study published in the journal Proceedings of the National Academy of Sciences. Though still in development, the test may someday be used to diagnose other degenerative brain disorders and even mild cognitive impairment resulting from head injuries.

The researchers say that using the test, they were able to identify Alzheimer’s patients with up to 86% sensitivity and specificity. (Sensitivity refers true positives identified by the test, while specificity refers to true negatives.) The test also differentiated Alzheimer’s from dementia with Lewy bodies, a related condition, with 90% sensitivity and specificity.

The new test’s “accuracy is markedly higher than other tests being developed,” said senior study author Francis Martin, a professor in the School of Pharmacy and Biomedical Sciences at the University of Central Lancashire in the United Kingdom. “For such a simple test to be so predictive is very exciting.”
That said, he himself was surprised by the accuracy, given that other researchers have not achieved similar results using more sophisticated approaches, Martin wrote in an email.


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